Nedsatt konsentrasjon av aktiv metabolitt av kodein, risiko for nedsatt analgetisk effekt av kodein (fremfor alt med tanke på at pasienter som bruker metadon allerede har utviklet opioidtoleranse).Long-phrase research in mice and rats are actually done with the National Toxicology Application to review the carcinogenic risk of acetaminophen. In 2-

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